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A close-up shot of a cheesy Keto Chicken Casserole being scooped from a white baking dish with a wooden spatula.

Mediterranean Chicken Enchilada Casserole

This innovative casserole fuses the vibrant, fresh flavors of the Mediterranean with the comforting, layered style of a Mexican enchilada bake. Tender shredded chicken, spinach, sun-dried tomatoes, and feta are rolled in tortillas, smothered in a zesty tomato-herb sauce, and baked to golden perfection.
Prep Time 35 minutes
Cook Time 35 minutes
Total Time 1 hour 10 minutes
Servings: 6 servings
Course: Main Course
Cuisine: Fusion, Mediterranean, Mexican
Calories: 550

Ingredients
  

For the Chicken Filling
  • 2 lbs boneless, skinless chicken breasts or 3 cups cooked, shredded chicken
  • 1 tbsp olive oil
  • 1/2 tsp salt
  • 1/4 tsp black pepper
  • 5 oz fresh spinach roughly chopped
  • 1/2 cup sun-dried tomatoes packed in oil, drained and chopped
  • 1/2 cup crumbled feta cheese
  • 1/4 cup Kalamata olives pitted and sliced
  • 2 tbsp fresh parsley chopped
  • 1 tsp dried oregano
For the Mediterranean Enchilada Sauce
  • 1 tbsp olive oil
  • 1/2 yellow onion finely chopped
  • 2 cloves garlic minced
  • 28 oz crushed tomatoes
  • 1/2 cup vegetable broth or chicken broth
  • 1 tbsp dried oregano
  • 1/2 tsp dried basil
  • 1/4 tsp red pepper flakes optional
  • 1/2 tsp salt
  • 1/4 tsp black pepper
  • 1 tbsp fresh lemon juice
  • 1 tbsp fresh parsley chopped, for garnish
For Assembly
  • 10-12 large flour tortillas 8-inch size
  • 1 cup shredded mozzarella cheese or a blend of mozzarella and provolone

Equipment

  • 9x13 inch baking dish
  • Large mixing bowl
  • Medium saucepan
  • Large Skillet
  • Cutting board
  • Sharp knife
  • Measuring cups and spoons

Method
 

Prepare the Chicken and Filling
  1. Season chicken breasts with 1/2 tsp salt and 1/4 tsp pepper. In a large skillet, heat 1 tbsp olive oil over medium-high heat. Add chicken and cook for 5-7 minutes per side, or until cooked through. Remove chicken, let cool slightly, then shred using two forks or an electric mixer.
  2. In a large mixing bowl, combine the shredded chicken, chopped spinach, drained and chopped sun-dried tomatoes, crumbled feta cheese, sliced Kalamata olives, 2 tbsp fresh parsley, and 1 tsp dried oregano. Mix well to combine.
Make the Mediterranean Enchilada Sauce
  1. In a medium saucepan, heat 1 tbsp olive oil over medium heat. Add finely chopped yellow onion and sauté for 3-5 minutes until softened. Add minced garlic and cook for another minute until fragrant.
  2. Stir in the crushed tomatoes, vegetable broth, 1 tbsp dried oregano, dried basil, red pepper flakes (if using), 1/2 tsp salt, and 1/4 tsp black pepper. Bring to a simmer, then reduce heat to low and cook for 10-15 minutes, stirring occasionally, allowing the flavors to meld and the sauce to thicken slightly.
  3. Remove from heat and stir in the fresh lemon juice.
Assemble the Casserole
  1. Preheat oven to 375°F (190°C). Lightly grease a 9x13 inch baking dish.
  2. Spread about 1/2 cup of the Mediterranean enchilada sauce on the bottom of the prepared baking dish.
  3. Warm the tortillas slightly in the microwave for 15-30 seconds to make them more pliable.
  4. Spoon approximately 1/4 to 1/3 cup of the chicken filling onto the center of each tortilla. Roll up the tortilla tightly and place seam-side down in the baking dish. Repeat with the remaining tortillas and filling, arranging them in a single layer in the dish.
  5. Pour the remaining Mediterranean enchilada sauce evenly over the rolled tortillas.
  6. Sprinkle the shredded mozzarella cheese over the top of the sauce.
Bake the Casserole
  1. Bake for 25-30 minutes, or until the sauce is bubbly and the cheese is melted and lightly golden.
  2. Remove from the oven and let rest for 5-10 minutes before serving. Garnish with fresh chopped parsley if desired.

Notes

Make Ahead: You can assemble the entire casserole a day in advance, cover it tightly, and refrigerate. Add an extra 10-15 minutes to the baking time if baking from cold.
Vegetarian Option: Omit the chicken and replace with 2 cans (15 oz each) drained cannellini beans or chickpeas, or 1.5 cups cooked quinoa, for a delicious meat-free alternative.
Spice Level: Adjust the red pepper flakes in the sauce to your preference for a spicier kick.
Storage: Leftovers can be stored in an airtight container in the refrigerator for up to 3-4 days.